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Glucosamine MSM Complex

The body manufactures glucosamine, a simple molecule composed of glucose and an amine (nitrogen and two molecules of hydrogen). Glucosamine is an important building block needed by the body to manufacture specialised molecules called glycosaminoglycans, found in cartilage. Glucosamine also promotes the incorporation of sulphur into cartilage. Glucosamine is almost exclusively researched and used for the treatment of osteoarthritis (OA).

Detailed human studies on the absorption, distribution, and elimination of orally administered glucosamine sulphate show an absorption rate as high as 98%. Once absorbed, it is taken up by the joint tissues, where it is incorporated into the connective tissue matrix of cartilage, ligaments, and tendons.

Sulphur is an essential nutrient for joint tissue, with research from the 1930s showing that arthritic individuals are commonly deficient in this mineral. The restoration of sulphur levels in these patients has been shown to bring about significant benefit.

Viridian uses glucosamine sulphate 2KCL which stands for 2 x molecules of Potassium (K) chloride (Cl), this is the preferred form rather than sodium chloride - thus eliminating any potential hypertensive effect.



MSM is a naturally occurring nutrient, an organic sulphur compound that is found in the normal human diet. MSM is found in foods, including fruit, alfalfa, corn, tomatoes, tea, and coffee. Sulphur is present in all living organisms and without sulphur life as we know it would not exist. It is an important element in more than 150 compounds in the body--tissues, enzymes, hormones, antibodies and antioxidants. Sulphur is stored in every cell of the body, particularly in the hair, nails and connective tissue of joints and skin, where it is an important structural protein component. Connective tissue supports and connects the internal organs, forms the walls of blood vessels, and joins muscles to bones.

VIRIDIAN GREEN FOOD BLEND (Wheat grass, bilberry fruit, barley grass, alfalfa)

Provides a potent mix of organic superfoods known for their abundance of synergistic nutrients including; trace minerals, antioxidants, enzymes, and other useful phytonutrients. This formula acts as a natural excipient providing additional nutritional value and aiding the absorption and delivery of the product.


Up to 2000mg /day of glucosamine have been used in studies. For obese individuals up to 20mg of glucosamine per kg of body weight is suggested. Methylsulfonylmethane is one of the least toxic substances in biology, similar in toxicity to water. According to research done at the MSM clinic at the Oregon Health Sciences University, long-term use of MSM at a dose greater than 2 g/day is well tolerated, producing no adverse effects.

Potential applications

Osteoarthritis - repair and healing resulting in relief of pain and inflammation, disorders of tendons, ligaments, and cartilage. MSM's high sulphur content may also prove helpful in treating similar diseases such as rheumatoid arthritis, systemic lupus erythematosus and temporal mandibular joint dysfunction (TMJ). Other Reported uses for MSM in humans include treatment for conditions such as hyperacidity, detoxification, constipation, musculoskeletal pain, allergies, and for immuno-modulation. Other scientists are investigating the relationship between MSM and asthma, dermatological problems, periodontal conditions, and even such disparate conditions as Alzheimer's disease and cancer.

Known contraindications

Manufactured glucosamine is synthetically derived from shellfish. Those with known chronic allergies should consult their physician. At the amount most frequently taken by adults-500 mg three times per day of glucosamine sulphate-adverse effects have been limited to mild reversible gastrointestinal side effects.


Research has raised the possibility that glucosamine could contribute to insulin resistance. This effect might theoretically result from the ability of glucosamine to interfere with an enzyme needed to regulate blood sugar levels. However, available evidence does not suggest that taking glucosamine supplements will trigger or aggravate insulin resistance or high blood sugar. Those with peptic ulcers and individuals taking diuretic drugs may be more likely to experience gastrointestinal side effects with glucosamine or MSM.

Use in conjunction with

  • Osteoarthritis - multi-phytonutrient complex, flax seed oil, boswellia, green food blend / malic acid (to reduce systemic acidity).
  • Dietary - increase water intake, reduce animal fats, and increase plant foods. Regular exercise and flexibility movements. Achieving appropriate body mass index (BMI) will reduce the risk of OA.

Glucosamine with MSM delivers a high net sulphur yield and thus may offer more potential in immune related arthritic conditions and for gut disorders linked to musculo-skeletal problems.


MSM is the modern name for brimstone. It is a white, odourless, slightly bitter tasting crystalline substance which contains 34% elemental sulphur.


© Cheryl Thallon at Viridian

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